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Category: TransportersarrowNeurotransmitter Transportersarrow5-HT Transporters
Cat.No. Product Name
1033 Fluvoxamine maleate
Price and Availability

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Fluvoxamine maleate
Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone -O-(2-aminoethyl)oxime maleate

Biological Activity:

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.

Technical Data:

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M.Wt: 434.41
Formula: C15H21F3N2O2.C4H4O4
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [61718-82-9]

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    References:

    Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505. Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313. Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117. Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305.
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    Keywords: Fluvoxamine Maleate, Neurotransmitter Transporters, 5-HT Re-uptake Inhibitor, Tocris Bioscience
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