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Category:
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Ion Channels Potassium ChannelsOther Potasium Channels
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Cat.No.
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Product Name
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2867 |
Flupirtine maleate
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| Alternative name(s): |
D
9998 |
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Price and Availability
Click here for full price details of
Flupirtine maleate
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Chemical Name:
N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl
]carbamic acid ethyl ester maleate |
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Biological Activity:
Non-opioid analgesic with muscle relaxant
properties. Activates K+ channels and indirectly antagonises NMDA
receptors. Exhibits neuroprotective actions in a model of cerebral ischaemia in
mice and reduces apoptosis and necrosis induced by noxious stimuli.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Osborne et al
(1998) Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA
antagonist. Gen.Pharmacol. 30 255. Azad et al
(2004) The potassium channel modulator flupirtine shifts the frequency-response
function of hippocampal synapses to favour LTD in mice. Neurosci.Lett. 370
186. Yeung et al (2007) Molecular expression and pharmacological
identification of a role for Kv7 channels in murine vascular
reactivity. Br.J.Pharmacol. 151 758.
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or by Research Area
Keywords: Flupirtine Maleate, Potassium Channels, K+ Channel Activator, D 9998, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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