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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA SelectivearrowAgonists
Cat.No. Product Name
0306 (S)-(-)-5-Fluorowillardiine  
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(S)-(-)-5-Fluorowillardiine
Chemical Name: (S)-(-)-a-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)pyr idinepropanoic acid

Biological Activity:

A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).

Technical Data:

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M.Wt: 217.16
Formula: C7H8FN3O4
Storage: Store at RT
Solubility: Soluble to 50 mM in 1.1eq. NaOH
Purity: >98%
CAS No: [140187-23-1]

Resources:

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    References:

    Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595. Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881. Hawkins et al (1995) Binding of the new radioligand (S)-[3H]-AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardine. Neuropharmacology 34 405. Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645.
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    Keywords: (S)-(-)-5-Fluorowillardiine, Ligand-gated Ion Channels, Very Potent AMPA Agonist, 5Fluorowillardiine, Tocris Bioscience
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