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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowBenzodiazepines
Cat.No. Product Name
1328 Flumazenil
Alternative name(s): Ro 15-1788
Price and Availability

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Flumazenil
Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1 ,4]benzodiazepine-3-carboxylic acid, ethyl ester

Biological Activity:

Benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo.

Technical Data:

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M.Wt: 303.29
Formula: C15H14FN3O3
Storage: Desiccate at +4°C
Solubility: Soluble to 25 mM in DMSO and to 5 mM in Ethanol
Purity: >99%
CAS No: [78755-81-4]

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    References:

    Polc et al (1981) Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788. Naunyn-Schmied.Arch.Pharmacol. 316 317. Atack et al (1999) Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors. Neuropsychopharmacology 20 255. Doble (1999) New insights into the mechanism of action of hypnotics. J.Psychopharmacol. 13 S11.
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    Keywords: Flumazenil, Ligand-gated Ion Channels, Benzodiazepine Antagonist, Ro 15-1788, Tocris Bioscience
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