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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH1 ReceptorsarrowAntagonists
Cat.No. Product Name
2429 Fexofenadine hydrochloride
Alternative name(s): MDL 16455
Terfenidine
Price and Availability

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Fexofenadine HCl
Chemical Name: a,a-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)- 1-piperidinyl]butyl]-benzeneacetic acid hydrochloride

Biological Activity:

Selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of terfenadine that displays non-sedating anti-allergic effects.  

Technical Data:

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M.Wt: 538.12
Formula: C32H39NO4.HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 50 mM in DMSO
Purity: >99%
CAS No: [153439-40-8]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269. Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76. Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205.
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    Keywords: Fexofenadine HCl, Histamine Receptors, H1 Receptor Antagonist; Non-sedating Antiallergic Agent, MDL 16455, Terfenidine, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Histamine Receptors
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    Purity To Rely On
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