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Category: EnzymesarrowKinasesarrowRho-kinases
Cat.No. Product Name
0541 Fasudil hydrochloride  
Alternative name(s): HA 1077
Price and Availability

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Fasudil hydrochloride
Chemical Name: 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride

Biological Activity:

Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.

Technical Data:

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M.Wt: 327.83
Formula: C14H17N3O2S.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >98%
CAS No: [103745-39-7]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Shirotani et al (1992) A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture. J.Pharmacol.Exp.Ther. 259 738. Arai et al (1993) Inhibition by the protein kinase inhibitor HA-1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. Satoh et al (1996) Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils. Br.J.Pharmacol. 118 1592. Sward et al (2000) Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum. J.Physiol. 522 33.
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    Keywords: Fasudil Hydrochloride, Kinases, Inhibitor Of Cyclic Nucleotide Dependent- & Rho-kinases, HA 1077, Tocris Bioscience
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