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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT2 Receptorsarrow5-HT2A
Cat.No. Product Name
0523

4F 4PP oxalate  

Price and Availability

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4F 4PP oxalate
Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate

Biological Activity:

A selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).

Technical Data:

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M.Wt: 429.49
Formula: C22H26FNO.C2H2O4
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 20 mM in Ethanol
Purity: >99%

Resources:

  • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch
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    References:

    Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903. Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153.
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    Keywords: 4F 4PP Oxalate, 5-HT Receptors, Selective 5-HT2A Antagonist, 4F4PP Oxalate, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    5-HT Receptors & their Ligands
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    Purity To Rely On
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    This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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