FRATide | Kinases | GSK-3 Inhibitor

Category:

Cat.No.	Product Name
1835	FRATide

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FRATide

Biological Activity:

Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalysed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B.

Technical Data:

M.Wt:	4534.11
Formula:	C₁₉₂H₃₂₇N₆₇O₆₀
Storage:	Desiccate at -20°C
CAS No:	[251087-38-4]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

References:

Thomas et al (1999) A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and β-catenin. FEBS Lett. 458 247. Bax et al (2001) The structure of phosphorylated GSK-3β complexed with peptide, FRATtide, that inhibits β-catenin phosphorylation. Structure 9 1143.

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Keywords: FRATide, Kinases, GSK-3 Inhibitor, Tocris Bioscience

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