Chemical Name:2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-c
arboxylic acid methyl ester
Biological Activity:
Potent activator of L-type Ca2+
channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat.
No. 1544) as a positive inotrope in guinea pig atria.
Zhenget al (1991) Pharmacological,
radioligand binding, and electrophysiological characteristics of FPL 64176, a
novel nondihydropyridine Ca2+ channel activator, in cardiac and
vascular preparations. Mol.Pharmacol. 40 734. Baxteret
al (1993) Discovery and synthesis of methyl
2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL
64176) and analogues: the first examples of a new class of calcium channel
activator. J.Med.Chem. 36 2739. Rampeet al (1993)
Comparison of the in vitro and in vivo cardiovascular effects of
two structurally distinct Ca++ channel activators, BAY K 8644 and
FPL 64176. J.Pharmacol.Exp.Ther. 265 1125.
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