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Category: EnzymesarrowKinasesarrowProtein Kinase B/Akt
Cat.No. Product Name
2926 FPA 124
Price and Availability

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FPA 124

Other Information:

Sold under licence from Wayne State University
Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene] hydrazinecarbothioamide copper complex

Biological Activity:

Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumour load in vivo.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 381.73
Formula: C11H9Cl2CuN3O2S
Storage: Store at +4°C
Solubility: Soluble to 10 mM in DMSO and to 10 mM in Ethanol
CAS No: [902779-59-3]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
    Product/Material Safety Data Sheet: View current batch

    References:

    Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800.
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    Keywords: FPA 124, Kinases, PKB / Akt Inhibitor, FPA124, Tocris Bioscience
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