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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowBenzodiazepines
Cat.No. Product Name
0554 FG 7142  
Price and Availability

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FG 7142
Chemical Name: N-Methyl-b-carboline-3-carboxamide

Biological Activity:

Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.

Technical Data:

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M.Wt: 225.25
Formula: C13H11N3O
Storage: Store at RT
Solubility: Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
Purity: >99%
CAS No: [78538-74-6]

Resources:

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    References:

    Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313. Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn-Schmied.Arch.Pharmacol. 340 352. Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355. Wettstein (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219.
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    Keywords: FG 7142, Ligand-gated Ion Channels, Benzodiazepine Inverse Agonist, FG7142, Tocris Bioscience
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