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Category:
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Enzymes IsomerasesDNA Topoisomerase
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Cat.No.
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Product Name
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1226 |
Etoposide
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Price and Availability
Click here for full price details of
Etoposide
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Chemical Name:
[5R-[5a,5ab,8aa,9b(R*)]]-9-[(4,6-0-Ethylidene-b-D-gluco
pyransoyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dim
ethoxyphenyl)furo[3',4':6,7]naptho[2,3-d]-1,3-dioxol-6-
(5aH)-one |
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Biological Activity:
Topoisomerase II inhibitor (IC50 = 59.2 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Terada et al (1993) Antitumor agents.3.Synthesis and biological
activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of
4¢-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
J.Med.Chem. 36 1689. Burden et al (1996)
Toposiomerase II.etoposide interactions direct the formation of drug-induced
enzyme-DNA cleavage complexes. J.Biol.Chem. 271 29238. Hande
et al (1998) Etoposide: four decades of development of a topoisomerase
II inhibitor. Eur.J.Cancer 34 1514.
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or by Research Area
Keywords: Etoposide, Isomerases, Topoisomerase II Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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