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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowOther
Cat.No. Product Name
1471 Etomidate
Price and Availability

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Etomidate
Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester

Biological Activity:

General anaesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.

Technical Data:

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M.Wt: 244.29
Formula: C14H16N2O2
Storage: Store at RT
Solubility: Soluble to 100 mM in Ethanol and to 50 mM in 1eq. HCl
Purity: >99%
CAS No: [33125-97-2]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Giese et al (1983) Etomidate: a new intravenous anesthetic induction agent. Pharmacother. 3 251. Belelli et al (1997) The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.USA 94 11031. Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABAA receptors. Toxicol.Lett. 100-101 209.
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    Keywords: Etomidate, Ligand-gated Ion Channels, GABA Mimetic & GABA Modulatory Agent, Tocris Bioscience
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