Beta-Estradiol | Estrogen & Related Receptors | Endogenous ER Ligand

Category:

Cat.No.	Product Name
2824	b-Estradiol

Price and Availability

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beta-Estradiol

Chemical Name: (17b)-Estra-1,3,5(10)-triene-3,17-diol

Biological Activity:

Endogenous estrogen receptor (ER) agonist (K_i values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

Technical Data:

M.Wt:	272.38
Formula:	C₁₈H₂₄O₂
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 75 mM in Ethanol
Purity:	>99%
CAS No:	[50-28-2]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinol. 138 863. Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinol. 146 624.

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Keywords: Beta-Estradiol, Estrogen & Related Receptors, Endogenous ER Ligand, Tocris Bioscience

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Product Feature

Estrogen Receptors

Key estrogen receptors available from Tocris include:

2662 PHTPP

Selective ERβ antagonist

2676 Y 134

Selective estrogen receptor modulator

2183 ZK 164015

Potent estrogen receptor silent antagonist

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