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Category: EnzymesarrowKinasesarrowSyk Kinase
Cat.No. Product Name
2471 ER 27319 maleate
Price and Availability

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ER 27319
Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate

Biological Activity:

Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FceRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signalling events.

Technical Data:

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M.Wt: 396.17
Formula: C18H20N2O.C4H4O4
Storage: Desiccate at +4°C
Solubility: Soluble to 75 mM in Water
Purity: >99%
CAS No: [201010-95-9]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Moriya et al (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcε receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA 94 12539. Luskova and Draber (2004) Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 10 1727.
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    Keywords: ER 27319, Kinases, Selective Syk Kinase Inhibitor, ER27319, Tocris Bioscience
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