EHNA Hydrochloride | Deaminases | Adenosine Deaminase Inhibitor

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Cat.No.	Product Name
1261	EHNA hydrochloride

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EHNA hydrochloride

Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride

Biological Activity:

Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC₅₀ = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase.

Technical Data:

M.Wt:	313.83
Formula:	C₁₄H₂₃N₅O.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water and to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>98%
CAS No:	[51350-19-7]

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References:

Bessodes et al (1982) Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition. Biochem.Pharmacol. 31 879. Podzuweit et al (1995) Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine. Cell.Signal. 7 733. Michie et al (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell.Signal. 8 97.

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Keywords: EHNA Hydrochloride, Deaminases, Adenosine Deaminase Inhibitor, Tocris Bioscience

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