1-EBIO | Potassium Channels | Activator Of Epithelial Kca Channels | 1EBIO

Category:

Cat.No.	Product Name
1041	1-EBIO

Price and Availability

Click here for full price details of
1-EBIO

Chemical Name: 1-Ethyl-2-benzimidazolinone

Biological Activity:

Activator of epithelial K_Ca channels, stimulates a large and sustained trans-epithelial Cl^- secretory response across T84 monolayers. Induces hyperpolarisation to the same magnitude as ACh in aortic value endothelial cells.

Technical Data:

M.Wt:	162.19
Formula:	C₉H₁₀N₂O
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[10045-45-1]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Devor et al (1996) Modulation of Cl^- secretion by benzimidazolones. I. Direct activation of a Ca²⁺ - dependent K⁺ channel. Am.J.Physiol. 271 L775. Ayotunde and Adeagbo (1999) 1-Ethyl-2-benzimidazolinone stimulates endothelial K_Ca channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 379 151. Kusama et al (2005) Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 146 487.

View related products by Pharmacological Action or by Research Area

Keywords: 1-EBIO, Potassium Channels, Activator Of Epithelial Kca Channels, 1EBIO, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
View PDF

Unique & Diverse Compound Libraries

Tocriscreen Collections : For pricing and compound information click here

Fully annotated small molecule libraries for HTS, HCS and
chemical biology applications.

1120 compounds
Pre-dissolved in DMSO

Tocriscreen Total (250 μL/well)
Tocriscreen Mini (50 μL/well)

New Products in this Area

	2660	L-364,373
	KCNQ1 (K_VLQT1) channel activator, activates I_Ks
	2946	TRAM 34
	Highly selective IK_Ca1 channel inhibitor
	2867	Flupirtine maleate
	K⁺ channel activator
	2665	BMS 191011
	Potent Maxi-K channel opener (BK_Ca, K_Ca1.1)
	2661	UCL 2077
	Slow afterhyperpolarisation (sAHP) channel blocker
	2533	DPO-1
	Blocker of K_V1.5 channel and I_Kur current

for new product e-alerts

User ID
Password