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Category:
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Ion Channels Potassium ChannelsVoltage-Gated Potassium Channels
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Cat.No.
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Product Name
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1808 |
E-4031 dihydrochloride
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Price and Availability
Click here for full price details of
E-4031 dihydrochloride
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Chemical Name:
N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]
carbonyl]phenyl]methanesulfonamide dihydrochloride |
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Biological Activity:
Selective blocker of HERG K+ channels; inhibits the
rapid delayed-rectifier K+ current (IKr). Reversibly
prolongs action potential duration in guinea-pig papillary muscle and isolated
ventricular myocytes, without affecting Na+ or Ca2+ inward
currents. Class III antiarrhythmic agent.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Wettwer et
al (1991) Effects of the new class III antiarrhythmic drug E-4031 on
myocardial contractility and electrophysiological parameters.
J.Cardiovasc.Pharmacol. 17 480. Verheijck et al
(1995) Effects of the delayed rectifier current blockade by E-4031 on impulse
generation in single sinoatrial nodal myocytes of the rabbit. Circ.Res. 76
607. Ficker et al (2002) The binding site for channel blockers
that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related
gene (HERG) mutations. J.Biol.Chem. 277 4989.
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View related products by Pharmacological Action
or by Research Area
Keywords: E-4031 Dihydrochloride, Potassium Channels, K+ (HERG) Channel Blocker; Inhibits Rapid Delayed Rectifier K+ Current (IKr), E4031 Dihydrochloride, Tocris Bioscience
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