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Category:
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Enzymes Oxygenases/OxidasesCyclooxygenase
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Cat.No.
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Product Name
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1430 |
DuP 697
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Price and Availability
Click here for full price details of
DuP 697
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Chemical Name:
5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]
-thiophene |
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Biological Activity:
Potent and selective inhibitor of
cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1
respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in
vivo. Orally active.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Gans et al (1990)
Anti-inflammatory and safety profile of DuP 697, a novel orally effective
prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 254 180.
Gierse et al (1995) Expression and selective inhibition of the
constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305
479. Rossoni et al (2002) Inhibition of cyclo-oxygenase-2
exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.
Br.J.Pharmacol. 135 1540.
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or by Research Area
Keywords: DuP 697, Oxygenases / Oxidases, Cyclooxygenase (COX-2) Inhibitor, DuP697, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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