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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH1 ReceptorsarrowAntagonists
Cat.No. Product Name
0508 Doxepin hydrochloride  
Price and Availability

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Doxepin hydrochloride
Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e] oxepin hydrochloride

Biological Activity:

Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).

Technical Data:

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M.Wt: 315.84
Formula: C19H21NO.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
CAS No: [1668-19-5]

Resources:

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    References:

    Merck Index 12 3492. Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501. Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006. Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427.
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    Keywords: Doxepin Hydrochloride, Histamine Receptors, Highly Potent H1 Antagonist. Also Binds To H4 Receptor, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Histamine Receptors
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