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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowKainate SelectivearrowAgonists
Cat.No. Product Name
0269

Domoic acid

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Domoic acid
Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E- hexadienyl)-3-pyrrolidineacetic acid

Biological Activity:

More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Technical Data:

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M.Wt: 311.33
Formula: C15H21NO6
Storage: Desiccate at -20°C
Solubility: Soluble to 50 mM in Water
CAS No: [14277-97-5]

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    References:

    Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345. Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29. Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. In Excitatory Amino Acids and Synaptic Plasticity. Ed. Y. Ben-Ari, p 49 Plenum Press, New York.
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    Keywords: Domoic Acid, Ligand-gated Ion Channels, Potent, Selective Kainate Agonist, Tocris Bioscience
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