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Category:
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Cellular Processes and Components Signal TransductionNitric Oxide SignallingOther Nitric Oxide
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Cat.No.
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Product Name
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0504 |
Diphenyleneiodonium chloride
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Price and Availability
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Diphenyleneiodonium chloride
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Chemical Name:
[1,1'-Biphenyl]-2,2'-diyliodonium chloride |
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Biological Activity:
Binds strongly to flavoproteins and is thus a potent inhibitor of
several important enzymes, including NO synthase, NADH reductase and oxidase.
Inhibits platelet aggregation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Yea et al (1990) Purification and some properties of the 45
kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.
Biochem.J. 265 95. Stuehr et al (1991) Inhibition
of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium
and its analogs. FASEB. 5 98. Wang et al (1993)
Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitro
and in vivo. Br.J.Pharmacol. 110 1232. Moore and Handy
(1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS
really good NOS for the nervous system? TiPS 18 204.
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View related products by Pharmacological Action
or by Research Area
Keywords: Diphenyleneiodonium Chloride, Signal Transduction, Binds To Flavoproteins & Inhibits NOS, Tocris Bioscience
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