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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH2 ReceptorsarrowAgonists
Cat.No. Product Name
0506 Dimaprit dihydrochloride  
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Dimaprit dihydrochloride
Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride

Biological Activity:

Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).

Technical Data:

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M.Wt: 234.19
Formula: C6H15N3S.2HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
CAS No: [23256-33-9]

Resources:

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    References:

    Parsons et al (1977) Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea]-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31. Durant et al (1977) Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39. Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331. Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169.

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    Keywords: Dimaprit Dihydrochloride, Histamine Receptors, Standard H2 Selective Agonist, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Histamine Receptors
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