Diltiazem Hydrochloride | Calcium Channels | Ca2+ Channel Blocker (L-type)

Category:

Cat.No.	Product Name
0685	Diltiazem hydrochloride

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Diltiazem hydrochloride

Chemical Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-d ihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

Biological Activity:

Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca²⁺ channels.

Technical Data:

M.Wt:	450.98
Formula:	C₂₂H₂₆N₂O₄S.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water
Purity:	>99%
CAS No:	[33286-22-5]

Resources:

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References:

Merck Index 12 3247. Dagani et al (1989) Effects of diltiazem on bioenergetics, K⁺ gradients, and free cytosolic Ca²⁺ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379. Ishibashi et al (1995) Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88. Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem. Br.J.Pharmacol. 118 1301. Kraus et al (1998) Molecular mechanisms of diltiazem interaction with L-type Ca²⁺ channels. J.Biol.Chem. 273 27205.

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Keywords: Diltiazem Hydrochloride, Calcium Channels, Ca2+ Channel Blocker (L-type), Tocris Bioscience

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