Dihydrokainic Acid | Neurotransmitter Transporters | EAAT2 (GLT-1)-selective Non-transportable Inhibitor Of L-glutamate & L-aspartate Uptake

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Transporters

Neurotransmitter Transporters

Glutamate Transporters

Cat.No.	Product Name
0111	Dihydrokainic acid

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Dihydrokainic acid

Chemical Name: (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

Biological Activity:

EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (K_i = 23 μM). 130-fold selective over EAAT1 and EAAT3 (K_i > 3 mM).

Technical Data:

M.Wt:	215.25
Formula:	C₁₀H₁₇NO₄
Storage:	Store at RT
Solubility:	Soluble to 25 mM in Water and to 100 mM in Phosphate buffered saline
CAS No:	[52497-36-6]

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References:

Munoz et al (1987) Effects of dihydrokainic acid on extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology 26 1. Arriza et al (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J.Neurosci. 14 5559. Kanal et al (1994) The neuronal and epithelial high affinity glutamate transporter, insights into structure and mechanism of transport. J.Biol.Chem. 269 20599.

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Keywords: Dihydrokainic Acid, Neurotransmitter Transporters, EAAT2 (GLT-1)-selective Non-transportable Inhibitor Of L-glutamate & L-aspartate Uptake, Tocris Bioscience

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