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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowAntagonists
Cat.No. Product Name
2349 Dihydro-b-erythroidine hydrobromide
Alternative name(s): DHbE
Price and Availability

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Dihydro-beta-erythroidine
Chemical Name: (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H- benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide

Biological Activity:

Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Antagonises behavioural effects of nicotine in vivo.

Technical Data:

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M.Wt: 356.26
Formula: C16H21NO3.HBr
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [29734-68-7]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Williams and Robinson (1984) Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue. J.Neurosci. 4 2906. Damaj et al (1995) In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice. Psychopharmacology 117 67. Harvey et al (1996) Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor α subunits. J.Neurochem. 67 1953.
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    Keywords: Dihydro-beta-erythroidine, Ligand-gated Ion Channels, Antagonist For Neuronal A4-containing Nicotinic Receptors, DHbE, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
    Nicotinic Receptors
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