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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowGlycine SitearrowAntagonists
Cat.No. Product Name
0286

5,7-Dichlorokynurenic acid  

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5,7-Dichlorokynurenic acid
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid

Biological Activity:

Potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Technical Data:

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M.Wt: 258.06
Formula: C10H5CI2NO3
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity: >98%
CAS No: [131123-76-7]

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    References:

    Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554. Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth Int.Symp.Med.Chem.Jerusalem 1990 p.29.
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    Keywords: 5,7-Dichlorokynurenic Acid, Ligand-gated Ion Channels, Potent NMDA Antagonist, Acts Glycine Site, 5,7Dichlorokynurenic Acid, Tocris Bioscience
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