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Category:
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7TM Receptors Adrenergic ReceptorsAlpha-2 ReceptorsAgonists
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Cat.No.
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Product Name
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2749 |
Dexmedetomidine hydrochloride
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| Alternative name(s): |
d-Medetomidine |
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Price and Availability
Click here for full price details of
Dexmedetomidine
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Chemical Name:
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
hydrochloride |
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Biological Activity:
Active isomer of Medetomide (Cat. No. 2023) a
potent, highly selective α2-adrenoceptor
agonist (Ki values are 1.08 and 1750 nM for α2-
and α1-adrenoceptors
respectively). Displays greater selectivity over α1-adrenoceptors
than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in
vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and
analgesic effects.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Savola et
al (1986) Evidence for medetomidine as a selective and potent agonist at
alpha 2-adrenoceptors. J.Aut.Pharmacol. 6 275. Virtanen et
al (1988) Characterization of the selectivity, specificity and potency of
medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol.
150 9. Scheinin et al (1989) Medetomidine -
a novel α2-adrenoceptor
agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat.
13 635. Fisher et al
(1991) Antinociceptive properties of intrathecal dexmedetomidine in rats.
Eur.J.Pharmacol. 192 221.
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or by Research Area
Keywords: Dexmedetomidine, Adrenergic Receptors, Active Isomer Of Cat. No. 2023, D-Medetomidine, Tocris Bioscience
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