N-Desmethylclozapine | 5-HT Receptors | 5-HT2C Antagonist | Normethylclozapine | NDesmethylclozapine

Category:

7TM Receptors

5-HT Receptors

5-HT2 Receptors

5-HT2C

Cat.No.

Product Name

1007

N-Desmethylclozapine

Alternative name(s):

Normethylclozapine

N-Desmethylclozapine C17H17ClN4 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

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N-Desmethylclozapine

Chemical Name: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepi ne

Biological Activity:

A major metabolite of clozapine; a potent and selective 5-HT_2C serotonin receptor antagonist.

Technical Data:

M.Wt:	312.8
Formula:	C₁₇H₁₇ClN₄
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[6104-71-8]

Resources:

Certificate of Analysis / MSDS:

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References:

Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT_1C receptor antagonists. Eur.J.Pharmacol.Mol.Pharmacol.Sect. 245 179. Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharmacol. 301 27. Wong et al (1996) Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABA_A receptors. Eur.J.Pharmacol. 314 319.

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Keywords: N-Desmethylclozapine, 5-HT Receptors, 5-HT2C Antagonist, Normethylclozapine, NDesmethylclozapine, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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