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Category:
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Cellular Processes and Components Cell MetabolismRNA and Protein Synthesis
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Cat.No.
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Product Name
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1467 |
Daunorubicin hydrochloride
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| Alternative name(s): |
Daunomycin |
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Price and Availability
Click here for full price details of
Daunorubicin hydrochloride
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Chemical Name:
(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-
hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydrox
y-1-methoxy-5,12-naphthacenedione hydrochloride |
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Biological Activity:
Anticancer agent that is clinically used to
treat nonlymphocytic leukaemia. Inhibits RNA and DNA synthesis and causes DNA
fragmentation in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Aubel-Sadron and Londos-Gagliardi
(1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a
physicochemical and biological review. Biochimie 66 333. Gewirtz
(1999) A critical evaluation of the mechanisms of action proposed for the
antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
Biochem.Pharmacol. 57 727. Laurent and Jaffrezou (2001)
Signaling pathways activated by daunorubicin. Blood 98 913.
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View related products by Pharmacological Action
or by Research Area
Keywords: Daunorubicin Hydrochloride, Cell Metabolism, RNA Synthesis Inhibitor, Daunomycin, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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