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Dantrolene, sodium salt
Chemical Name:1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-i
midazolinedione sodium salt
Biological Activity:
Inhibits release of Ca2+
from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR)
channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against
the effects of a variety of conditions and agents, including excitatory amino
acids. Skeletal muscle relaxant and neuroprotectant.
Merck
Index 12 2879. Hotchkiss andKarl (1994) Dantrolene
ameliorates the metabolic hallmarks of sepsis in rats and improves survival in
a mouse model of endotoxemia. Proc.Natl.Acad.Sci.USA. 91 3039. O'Mara
et al (1995) Dantrolene inhibits long-term depression and
depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 68
621. Zhao et al (2001) Dantrolene inhibition of ryanodine
receptor Ca2+ release channels. J.Biol.Chem.27613810.
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