D-AP5

Alternative name(s):	2-APV
	D-APV
	D-2-amino-5-phosphonovalerate
	D-Aminophosphonovaleric acid

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Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid

Biological Activity:

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (0107).

Technical Data:

M.Wt:	197.13
Formula:	C₅H₁₂NO₅P
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water
Purity:	>99 %
CAS No:	[79055-68-8]

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References:

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203.

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Keywords: D-AP5, Ligand-gated Ion Channels, More Active Form Of DL-AP5 (0105), Tocris Bioscience

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