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Category:
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Enzymes PolymerasesPoly(ADP-ribose) Polymerase
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Cat.No.
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Product Name
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2496 |
DR 2313
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Price and Availability
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DR 2313
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Chemical Name:
1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimid
in-4-one |
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Biological Activity:
Potent,
competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50
values are 0.20 and 0.24 μM for PARP-1 and PARP-2
respectively). Neuroprotective; reduces neuronal cell death in models of
cerebral ischaemia in vivo and in vitro. Brain-penetrant.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Nakajima et al (2005) A newly
synthesized poly(ADP-ribose) polymerase inhibitor, DR2313
[2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]:
pharmacological profiles, neuroprotective effects, and therapeutic time window
in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472. Jagtap
and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of
its inhibitors. Nat.Rev.Drug Discov. 4 421.
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View related products by Pharmacological Action
or by Research Area
Keywords: DR 2313, Polymerases, Potent PARP Inhibitor, DR2313, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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