DPN | Estrogen & Related Receptors | Highly Potent ERb Agonist | Diarylpropionitrile

Category:

Nuclear Receptors

Estrogen and Related Receptors

Cat.No.

Product Name

1494

DPN

Alternative name(s):

Diarylpropionitrile

DPN C15H13NO2 2,3-bis(4-Hydroxyphenyl)-propionitrile

Price and Availability

Click here for full price details of
DPN

Chemical Name: 2,3-bis(4-Hydroxyphenyl)-propionitrile

Biological Activity:

Highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC₅₀ values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro.

Technical Data:

M.Wt:	239.27
Formula:	C₁₅H₁₃NO₂
Storage:	Desiccate at -20°C
Solubility:	Soluble to 30 mM in 1eq. NaOH and to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[1428-67-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Meyers et al (2001) Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J.Med.Chem. 44 4230. Harrington et al (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 206 13. Montgomery et al (2003) Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility. Br.J.Pharmacol. 139 1249.

View related products by Pharmacological Action or by Research Area

Keywords: DPN, Estrogen & Related Receptors, Highly Potent ERb Agonist, Diarylpropionitrile, Tocris Bioscience

New Product Guide

	Our latest New Product Guide highlights over 140 new products.
Request Copy / View PDF

Product Feature

Estrogen Receptors

Key estrogen receptors available from Tocris include:

2662 PHTPP

Selective ERβ antagonist

2676 Y 134

Selective estrogen receptor modulator

2183 ZK 164015

Potent estrogen receptor silent antagonist

View Product Feature

New Products in this Area

	2823	α-Estradiol
	Endogenous estrogen receptor ligand
	2824	β-Estradiol
	Endogenous ER ligand
	2676	Y 134
	Selective estrogen receptor modulator (SERM), selective for ERα
	2662	PHTPP
	Selective ERβ antagonist

for new product e-alerts

User ID
Password