DPDPE | Opioid Receptors | D-receptor Agonist | [D-Pen2,5]Enkephalin | [D-Pen2,D-Pen5]Enkephalin

Category:

7TM Receptors

Opioid Receptors

Delta Receptors

Agonists

Cat.No.

Product Name

1431

DPDPE

Alternative name(s):	[D-Pen^2,5]Enkephalin
	[D-Pen²,D-Pen⁵]Enkephalin

Price and Availability

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DPDPE

Biological Activity:

Prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC₅₀ = 5.2 nM), and is antinociceptive in vivo.

Technical Data:

M.Wt:	645.79
Formula:	C₃₀H₃₉N₅O₇S₂
Storage:	Desiccate at -20°C
CAS No:	[88373-73-3]

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Certificate of Analysis / MSDS:

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References:

Clark et al (1986) [D-Pen²,D-Pen⁵]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ₁ opiate binding sites. Eur.J.Pharmacol. 128 303. Chandrakumar et al (1992) Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly³-Phe⁴ amide bond isostere substitutions. J.Med.Chem. 35 2928. Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen^2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat. J.Pharmacol.Exp.Ther. 295 1135.

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Keywords: DPDPE, Opioid Receptors, D-receptor Agonist, [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin, Tocris Bioscience

Literature in this Area

Scientific Reviews

Opioid Receptors
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