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Category: EnzymesarrowKinasesarrowDNA-dependent Protein Kinase
Cat.No. Product Name
2088 DMNB
Price and Availability

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DMNB
Chemical Name: 4,5-Dimethoxy-2-nitrobenzaldehyde

Biological Activity:

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analogue vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

Technical Data:

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M.Wt: 211.15
Formula: C9H9NO5
Storage: Store at -20°C
Solubility: Soluble to 25 mM in Ethanol and to 100 mM in DMSO
Purity: >98%
CAS No: [20357-25-9]

Resources:

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    • Certificate of Analysis / MSDS:

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    No Product/Material Safety Data Sheet available.
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    References:

    Durant and Karran (2003) Vanillins - a novel family of DNA-PK inhibitors. Nucleic Acids Res. 31 5501.
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    Keywords: DMNB, Kinases, DNA-dependent Protein Kinase Inhibitor, Tocris Bioscience
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