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Chemical Name:4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N
,N-dimethylbenzenamine dihydrochloride
Biological Activity:
Partial agonist at α7-containing neuronal
nicotinic receptors and antagonist at α4β2 and other nicotinic
receptors. Displays specific cognition-enhancing effects; improves long-term
memory in rats.
Arendashet al (1995) Improved learning and memory in aged rats
with chronic administration of the nicotinic receptor agonist GTS-21. Brain
Res. 674 252. Kemet al (1997) Anabaseine is a
potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic
receptors. J.Pharmacol.Exp.Ther. 283 979. Stevenset al
(1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory
response in DBA mice. Psychopharmacology 136 320.
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