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(RS)-3,5-DHPG
Chemical Name:(RS)-3,5-Dihydroxyphenylglycine
Biological Activity:
Selective group I metabotropic glutamate receptor agonist which
activates both mGlu1 and mGlu5. Also reported to be an
antagonist at metabotropic glutamate receptors linked to phospholipase D.
Itoet al (1992) 3,5-Dihydroxyphenylglycine: a potent agonist
of metabotropic glutamate receptors. NeuroReport 3 1013. Pellegrini-Giampietroet al (1996) Pharmacological characterization of metabotropic glutamate
recpetors coupled to phopholipase D in the rat hippocampus. Br.J.Pharmacol. 118
1035. Mistryet al (1998) Regulation of phosphoinositide turnover
in neonatal rat cerebral cortex by group I- and II-selective metabotropic
glutamate receptor agonists. Br.J.Pharmacol. 123 581. Palmeret al (1998) The group I mGlu receptor agonist DHPG induces a novel form
of LTD in the CA1 region of the hippocampus. Neuropharmacology 36
1517.
Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.
