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Category:
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7TM Receptors Cannabinoid ReceptorsCB1 Receptors
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Cat.No.
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Product Name
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1485 |
DEA
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| Alternative name(s): |
Docosatetraenylethanolamide |
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Price and Availability
Click here for full price details of
DEA
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Chemical Name:
N-(2-Hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide |
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Biological Activity:
Potent endocannabinoid (anandamide analogue)
that activates CB1 receptors in microglia and binds to rat
synaptosomal membranes (KI = 34.4 nM). Cannabimimetic in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hanus et al
(1993) Two new unsaturated fatty acid ethanolamides in brain that bind to the
cannabinoid receptor. J.Med.Chem. 36 3032. Barg et al
(1995) Cannabinomimetic behavioral effects of and adenylate cyclase inhibition
by two new endogenous anandamides. Eur.J.Pharmacol. 287 145. Walter
et al (2001) Microglial cells produce endocannabinoids and express
functional cannabinoid receptors: evidence that docosatetraenylethanolamide
(DEA) is an additional endocannabinoid. Soc.Neurosci.Abstr. 634.16
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Keywords: DEA, Cannabinoid Receptors, Endogenous CB1 Agonist, Docosatetraenylethanolamide, Tocris Bioscience
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