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Category: EnzymesarrowKinasesarrowOther Kinases
Cat.No. Product Name
2755 DCA
Price and Availability

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DCA
Chemical Name: Dichloroacetate

Biological Activity:

Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumour growth in vitro and in vivo.

Technical Data:

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M.Wt: 150.92
Formula: C2HCl2NaO2
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
CAS No: [2156-56-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Stacpoole (1989) The pharmacology of dichloroacetate. Metabolism Clin.Exp. 38 1124. Bowker-kinley et al (1998) Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem.J. 329 191. Bonnet et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 37.
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    Keywords: DCA, Kinases, Mitochondrial Pyruvate Dehydrogenase Kinase (PDK) Inhibitor, Tocris Bioscience
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    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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