|
Category:
|
Enzymes EsterasesPhospholipase
|
|
Cat.No.
|
Product Name
|
|
1437 |
D609
|
|
|
|
Price and Availability
Click here for full price details of
D609
|
|
Chemical Name:
O-(Octahydro-4,7-methano-1H-inden-5-yl)
carbonopotassium dithioate |
|
|
Biological Activity:
Selective
competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki
= 6.4 μM); antiviral and antitumour agent. Suppresses LPS- and IFNγ-induced NO production (IC50
= 20 μg/ml) and blocks oxidative glutamate toxicity in nerve
cells. Antioxidant in vivo.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Tschiakowsky et al (1994) Induction of
nitric oxide synthase activity in phagocytic cells inhibited by
tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664. Amtmann
(1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of
phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22
287. Li et al (1998) Phosphatidylcholine-specific phospholipase C
regulates glutamate-induced nerve cell death. Proc.Natl.Acad.Sci.USA 95 7748.
Zhou et al (2001) D609 inhibits ionizing radiation-induced
oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298
103.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: D609, Esterases, Selective PC-PLC Inhibitor, Tocris Bioscience
|
