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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA / Kainate SelectivearrowDesensitization Modulators
Cat.No. Product Name
0713 Cyclothiazide  
Price and Availability

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Cyclothiazide
Chemical Name: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benz othiazidiazine-7-sulfonamide-1,1-dioxide

Biological Activity:

Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitisation. Selective for the flip variant of each of the four receptor subunits.

Technical Data:

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M.Wt: 389.87
Formula: C14H16ClN3O4S2
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity: >98%
CAS No: [2259-96-3]

Resources:

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    References:

    Desai et al (1995) Cyclothiazide acts at a site on the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognise competitive or noncompetitive AMPA receptor antagonists. J.Pharmacol.Exp.Ther. 272 38. Donevan and Rogawski (1998) Allosteric regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benzodiazepines. Neuroscience 87 615. Kessler et al (2000) The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits. Neurosci.Lett. 287 161.
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    Keywords: Cyclothiazide, Ligand-gated Ion Channels, AMPA Selective Desensitisation Inhibitor, Tocris Bioscience
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