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Category:
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Cellular Processes and Components Signal TransductionHedgehog Signalling
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Cat.No.
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Product Name
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1623 |
Cyclopamine
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Price and Availability
Click here for full price details of
Cyclopamine
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Chemical Name:
(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,
4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-
3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(
3'H)-furo[3,2-b]pyridin]-3-ol |
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Biological Activity:
Inhibitor of hedgehog (hh) signalling, likely
via direct inhibition of smoothened, the accessory protein to the putative hh
receptor patched. Anti-cancer and teratogenic in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Incardona et al (2000)
Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated
through effects on cholesterol transport. Dev.Biol. 224 440. Chen
et al (2002) Inhibition of hedgehog signaling by direct binding of
cyclopamine to smoothened. Genes Dev. 16 2743. King (2002)
Roughing up smoothened: chemical inhibitors of hedgehog signaling. J.Biol. 1
8. Scott (2003) Cancer: a twist in a hedgehog's tale. Nature 425
780.
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or by Research Area
Keywords: Cyclopamine, Signal Transduction, Inhibitor Of Hedgehog (hh) Signalling, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
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