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Category:
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Ion Channels Potassium ChannelsATP-Activated Potassium Channels
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Cat.No.
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Product Name
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1377 |
Cromakalim
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| Alternative name(s): |
BRL
34915 |
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Price and Availability
Click here for full price details of
Cromakalim
Other Information:
Sold under
licence
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Chemical Name:
trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyr
rolidinyl)-2H-1-benzopyran-6-carbonitrile |
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Biological Activity:
Prototypical KATP channel opener. Relaxes rabbit
isolated portal vein with an IC50 value of 21 nM . Potent, orally
active and hypotensive in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Escande et al (1988) The potassium channel opener cromakalim (BRL
34915) activates ATP-dependent K+ channels in isolated cardiac
myocytes. Biochem.Biophys.Res.Comm. 154 620. Wilson et
al (1988) Comparative effects of K+ channel blockade on the
vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol.
152 331. Longman et al (1988) Cromakalim, a
potassium channel activator: a comparison of its cardiovascular haemodynamic
profile and tissue specificity with those of pinacidil and nicorandil.
J.Cardiovasc.Pharmacol. 12 535.
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View related products by Pharmacological Action
or by Research Area
Keywords: Cromakalim, Potassium Channels, KATP Channel Opener, BRL 34915, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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