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Category:
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Enzymes PolymerasesTelomerase
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Cat.No.
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Product Name
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2483 |
Costunolide
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Price and Availability
Click here for full price details of
Costunolide
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Chemical Name:
(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethy
l-3-methylene-cyclodeca[b]furan-2(3H)-one |
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Biological Activity:
Inhibitor of human telomerase
activity (IC50 = 65 μM
in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis
in a variety of human tumour cell lines. Selectively blocks endothelial cell
proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β
and disrupts NF-κB activation. Displays
anti-inflammatory, anti-fungal and anti-viral properties.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Park et al (1996)
Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide,
a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi.
J.Nat.Prod. 59 1128. Jeong et al (2002)
Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR
KDR/Flk-1 signaling pathway. Cancer Lett. 187 129. Choi et
al (2005) Inhibitory effects of costunolide on the telomerase activity in
human breast carcinoma cells. Cancer Lett. 227 153.
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View related products by Pharmacological Action
or by Research Area
Keywords: Costunolide, Polymerases, Inhibitor Of Human Telomerase Activity, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..” Researcher, University of Pisa, Italy |
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