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Category:
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7TM Receptors Peptides (Gastrointestinal)Ghrelin Receptors
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Cat.No.
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Product Name
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3033 |
Cortistatin-8
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| Alternative name(s): |
CST-8 |
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Price and Availability
Click here for full price details of
Cortistatin-8
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Biological Activity:
Synthetic cortistatin analogue that lacks the
ability to bind somatostatin receptors but retains ghrelin receptor binding.
Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on
gastric acid secretion.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Luque et
al (2006) Cortistatin mimics somatostatin by inducing a dual,
dose-dependent stimulatory and inhibitory effect on growth hormone secretion in
somatotropes. J.Mol.Endocrinol. 36 547. Sibilia et al
(2006) Evidence for a role of the GHS-R1a receptors in ghrelin
inhibition of gastric acid secretion in the rat. J.Neuroendocrinol. 18
122. Prodam et al (2008) Cortistatin-8, a synthetic
cortistatin-derived ghrelin receptor ligand, does not modify the endocrine
responses to acylated ghrelin or hexarelin in humans. Neuropeptides 42
89.
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or by Research Area
Keywords: Cortistatin-8, Peptides (Gastrointestinal), Ghrelin Receptor Antagonist, CST-8, Tocris Bioscience
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