Combretastatin A4 | Cytoskeleton & Motor Proteins | Inhibits Tubulin Polymerisation. Antitumour, Antiangiogenic & Antimetastatic | CRC 87-09 | NSC 817373

Category:

Cellular Processes and Components

Cytoskeleton and Motor Proteins

Microtubules

Cat.No.

Product Name

1495

Combretastatin A4

Alternative name(s):	CRC 87-09
	NSC 817373

Price and Availability

Click here for full price details of
Combretastatin A4

Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phe nol

Biological Activity:

Antitumour, antiangiogenic and antimetastatic agent, in vitro and in vivo. Acts by inhibiting tubulin polymerisation (IC₅₀ = 2-3 μM).

Technical Data:

M.Wt:	316.35
Formula:	C₁₈H₂₀O₅
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	117048-59-6

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Pettit et al (1989) Isolation and structure of the cell growth and tubulin inhibitor combretastatin A-4. Experientia 45 209. Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131. Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821. Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Epx.Ther. 323 365.

View related products by Pharmacological Action or by Research Area

Keywords: Combretastatin A4, Cytoskeleton & Motor Proteins, Inhibits Tubulin Polymerisation. Antitumour, Antiangiogenic & Antimetastatic, CRC 87-09, NSC 817373, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
View PDF

Products You Can Trust

When you buy a product from Tocris you know you are buying the genuine article.

If we supply a patented product we will always seek to obtain a licence from the patent holder and ensure that our product meets or exceeds specifications.

Our reputation for integrity and uncompromising quality allows us to partner with world-class scientific organisations to bring novel and exclusive products to market.

New Products in this Area

	1495	Combretastatin A4
	Inhibits tubulin polymerisation. Antitumour, antiangiogenic and antimetastatic

for new product e-alerts

User ID
Password