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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
2456 Co 101244 hydrochloride
Alternative name(s): PD 174494
Ro 63-1908
Price and Availability

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Co 101244 HCl
Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl ]-4-piperidinol hydrochloride

Biological Activity:

Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Technical Data:

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M.Wt: 377.91
Formula: C21H27NO3.HCl
Storage: Store at +4°C
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [193359-26-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Zhou et al (1999) 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J.Med.Chem. 42 2993. Gill et al (2002) Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist. J.Pharmacol.Exp.Ther. 302 940. Higgins et al (2003) Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 44 324.
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    Keywords: Co 101244 HCl, Ligand-gated Ion Channels, Highly Selective NR2B Antagonist, PD 174494, Ro 63-1908, Co101244 HCl, Tocris Bioscience
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