Chemical Name:8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,
4]diazepine
Biological Activity:
Atypical antipsychotic drug, with a much lower tendency to cause
extrapyramidal side effects than conventional neuroleptics. Displays a broad
range of pharmacological actions; the antipsychotic effects are thought to be
mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki
values are 21, 170, 170, 230 and 330 nM for D4, D3, D1,
D2 and D5 receptors respectively).
Cantonet al (1990) Binding of typical and
atypical antipsychotics to 5-HT1C and 5-HT2 sites:
clozapine potently interacts with 5-HT1C sites. Eur.J.Pharmacol. 191
93. Ellenbroeket al (1991) The involvement of dopamine D1
and D2 receptors in the effects of the classical neuroleptic
haloperidol and the atypical neuroleptic clozapine. Eur.J.Pharmacol. 196 103.
Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS. 15
264. Travis (1997) Clozapine-review. J.Serotonin Res. 4
125.
