Clomipramine Hydrochloride | Neurotransmitter Transporters | 5-HT Re-uptake Inhibitor

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Cat.No.	Product Name
0457	Clomipramine hydrochloride

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Clomipramine hydrochloride

Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepi ne-5-propanamine hydrochloride

Biological Activity:

Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a K_i of 0.05 nmol/l.

Technical Data:

M.Wt:	351.32
Formula:	C₁₉H₂₃ClN₂.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water
CAS No:	[17321-77-6]

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References:

Merck Index 12 2447. McTavish and Benfield (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39 136. Ortiz and Artigas (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. Br.J.Pharmacol. 105 941. Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305.

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Keywords: Clomipramine Hydrochloride, Neurotransmitter Transporters, 5-HT Re-uptake Inhibitor, Tocris Bioscience

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5-HT Receptors & their Ligands
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